Interaction within and between cortical networks subserving multisensory learning and its reorganization due to musical expertise

Abstract

Recent advancements in the field of network science allow us to quantify inter-network information exchange and model the interaction within and between task-defined states of large-scale networks. Here, we modeled the inter- and intra- network interactions related to multisensory statistical learning. To this aim, we implemented a multifeatured statistical learning paradigm and measured evoked magnetoencephalographic responses to estimate task-defined state of functional connectivity based on cortical phase interaction. Each network state represented the whole-brain network processing modality-specific (auditory, visual and audiovisual) statistical learning irregularities embedded within a multisensory stimulation stream. The way by which domain-specific expertise re-organizes the interaction between the networks was investigated by a comparison of musicians and non-musicians. Between the modality-specific network states, the estimated connectivity quantified the characteristics of a supramodal mechanism supporting the identification of statistical irregularities that are compartmentalized and applied in the identification of uni-modal irregularities embedded within multisensory stimuli. Expertise-related re-organization was expressed by an increase of intra- and a decrease of inter-network connectivity, showing increased compartmentalization.