Abstract
Germinal centers play a key role in the maturation of the B cell immune response. Although the initial B cell triggering after interaction of the immunoglobulin receptor molecule with the antigen is thought to take place in the paracortical areas of lymph node and MALT, the isotype switch, affinity maturation and differentiation of B cells into memory cells all take place in the germinal center1-3. B cells that enter the germinal center divide rapidly. Through the process of somatic hypermutation a great heterogeneity in antigen binding specificity in the proliferating B cell population is generated4. However only cells with Ig receptors with high affinity for the antigen are selected for further maturation into memory cells, while the non selected cells die through a process of programmed cell death (PCD)5,6. PCD, also called apoptosis constitutes a cell elimination program, that involves generation of DNA strand breaks, chromatin condensation and cell fragmentation.KeywordsHigh Density CellAdhesion ReceptorFollicular Dendritic CellSomatic HypermutationFlat Bottom Tissue Culture Plate
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