Abstract
ABSTRACTWheat germ agglutinin (WGA) is the first studied plant lectin shown to bind more strongly to tumour cells than to normal ones. WGA interacts with prostate cancer cells, human pancreatic cells and colon-cancer cells.Our results showed the interaction of WGA with two porphyrin compounds—Fe porphyrin and Pdporphyrin. The dissociation constants for the porphyrin binding was kD (0.08–1.02 μM) showing high affinity for the two porphyrins for this protein. The hyperbolic titration curve indicated the presence of a single porphyrin binding site.In conclusion, we show that two photosentisizers with anticancer activity Fe porphyrin and Pd porphyrin, have high affinity for WGA. Since WGA binds to cancer cells, the results suggest that it may have utility in the targeted delivery of drugs for cancer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
