Abstract

Abstract : A precise, reproducible, and sensitive serum neutralization test was developed to estimate Venezuelan equine encephalomyelitis (VEE) serum- neutralizing antibodies within 24 hours. The test is dependent on both the interactions of virus with antiviral serum and the resultant complex with anti- gamma globulin (IgG) antibodies. The 50% serum-neutralizing end point was calculated from the reduction of number of fluorescent cells in McCoy cell monolayers resulting from the neutralization of infective viral particles by antibodies. In comparative estimates of neutralizing antibodies of human and monkey sera, the sensitivity of the serum neutralization anti-IgG test was several hundred times greater than that of the conventional mouse serum neutralization test.

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