Abstract
Interaction of various non-steroidal anti-inflammatory drugs (NSAIDs) and quinolone antimicrobials with γ-aminobutyric acid (GABA) A receptor-Cl − channel complex was investigated in rat dissociated hippocampal CA1 neurons by using whole-cell mode path-clamp technique. Neither NSAIDs nor quinolones alone affected the GABA-induced chloride current (I Cl). In the presence of norfloxacin (NFLX), one of quinolones, some NSAIDs suppressed the GABA response in a concentration-dependent manner. The inhibitory potency of NSAIDs was 4-biphenylacetic acid (BPA), a metabolite offenbufen≫indomethacin=naproxen>mefenamic acid>diclofenac>piroxicam. The results suggest that fenbufen, indomethacin and naproxen in the presence of quinolones may induce the epileptogenic neurotoxicities via pharmacological interaction with GABA A receptor.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
