Abstract
1. In rat parotid acini, vanadate affects amylase secretion and intracellular messengers according to its concentration. 2. Low concentrations (in the micromolar range) concentrations of vanadate stimulate amylase secretion and potentiate the secretory effect of carbamylcholine, but inhibit the amylase release in response to isoproterenol. 3. Vanadate increases inositol phosphates (mono-, bis- and trisphosphate) and potentiate the stimulatory effect of carbachol on inositol bis- and trisphosphate. 4. Vanadate also decreases the intracellular cyclic AMP concentration and the increase in response to isoproterenol or forskolin. 5. High concentrations (in the millimolar range) of vanadate inhibit the increase in inositol phosphate induced by carbachol. 6. It is concluded that low concentrations of vanadate activate regulatory proteins coupled to phospholipase C and adenylate cyclase while high concentrations of vanadate inhibit inositol bisphosphatase.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
