Abstract
α-Tocopherol (α-TOH) is thought to act as a lipid-soluble antioxidant by scavenging the chain-carrying lipid peroxyl radical (LOO .), giving rise to α-TO . and LOOH. The aim of the present work is to test the possibility that α-TOH may also exert a protective action by converting LOO . into the parent, unoxidized lipid molecule (LH) with concomitant formation of O 2 − and T +O. To assess the relative contribution of the two pathways, the amounts of products accumulating were measured, i.e. LOOH and O 2 −, under conditions where lipid peroxidation was initiated at linear rates by the UV light-induced decomposition of AIBN. The overall conclusion of the study is based on the observation that significant amounts of O 2 − were produced, whereas the ΔLOOH/Δα-TOH was considerably smaller than 1.0. A mechanism of one or two-electron oxidation of TOH is considered; according to it the phospholipid primary structure is restored (LOO . → LH, breaking of the CO bond). This leads to the oxygen or superoxide anion-radical release accordingly.
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