Abstract
The terpyridine appended glucosyl-conjugate ligand L and its complexes of Zn2+ (1) and Cu2+ (2) were synthesized and characterized by spectroscopy techniques. The changes in the absorption and fluorescence spectra of L in presence of Zn2+ and Cu2+ is supportive of interaction of L through terpyridyl metal binding core which was further confirmed by 1H NMR. The coordination and structural features emerged from the spectroscopy were used in order to optimize the structures of 1 and 2 by DFT computational calculations. The isolated complex 2 shows binding with ct-DNA through minor groove binding and intercalation modes and increases the thermal stability of ct-DNA by ∼20 °C. Due to the presence of Cu2+ in 2, this complex showed cleavage of the plasmid pBR322 through hydroxy radical formation. The presence of glucosyl moiety at both the ends of the complex 1 interacts with the WGA and imparts dendrimeric-like micro structures due to the protein aggregation as demonstrated by SEM.
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