Abstract
Naltrexone methyl bromide (NMB) caused alterations in both the amplitude and the time course of end-plate currents (EPC) recorded from rat muscle. The amplitudes were significantly lower than control, and the EPC decay was no longer singly exponential. There was also a decrease in the voltage dependence of the peak amplitude and the decay time constant of the EPCs. These findings suggest NMB is blocking the open state of the acetylcholine channel.
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