Abstract
1. The development of experimental diabetes mellitus involves increases in HHAS activity, resulting in hypertrophy of MSSPVNH neurons and their nucleoli, along with increases in the blood levels of CRF, ACTH, and glucocorticoids. 2. In animals with experimental diabetes mellitus, there are pronounced changes in the state of the peptidergic system in the MSSPVNH and the median eminence of the hypothalamus, indicating their participation in the pathogenesis of this type of diabetes.
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