Abstract
Interaction of the human respiratory Syncytial virus matrix protein with cellular adaptor protein complex 3 plays a critical role in trafficking
Highlights
Human Respiratory Syncytial Virus (HRSV) is the leading cause of acute lower respiratory tract infection (ALRI) in infants and it is estimated that globally 66,000–199,000 children younger than 5 years died from HRSV-associated ALRI in 2005 [1]
The results show that the interaction between HRSV M and AP-3Mu3A was specific in yeast two-hybrid system
We show the elucidation of a novel interaction between the AP-3 complex and the HRSV M protein through the AP-3Mu3A subunit, which plays a role in trafficking
Summary
Human Respiratory Syncytial Virus (HRSV) is the leading cause of acute lower respiratory tract infection (ALRI) in infants and it is estimated that globally 66,000–199,000 children younger than 5 years died from HRSV-associated ALRI in 2005 [1]. HRSV belongs to the Paramyxoviridae family and is an enveloped, negative sense, single-stranded RNA virus encoding 11 proteins [2]. HRSV infection occurs preferentially through the apical surface of the most superficial layer of the polarized epithelium of the respiratory tract [3, 4]. Human Respiratory Syncytial Virus matrix protein interacts with cellular adaptor protein complex 3
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