Abstract
Interaction of the human respiratory Syncytial virus matrix protein with cellular adaptor protein complex 3 plays a critical role in trafficking
Highlights
Human Respiratory Syncytial Virus (HRSV) is the leading cause of acute lower respiratory tract infection (ALRI) in infants and it is estimated that globally 66,000–199,000 children younger than 5 years died from HRSV-associated ALRI in 2005 [1]
The results show that the interaction between HRSV M and AP-3Mu3A was specific in yeast two-hybrid system
We show the elucidation of a novel interaction between the AP-3 complex and the HRSV M protein through the AP-3Mu3A subunit, which plays a role in trafficking
Summary
Human Respiratory Syncytial Virus (HRSV) is the leading cause of acute lower respiratory tract infection (ALRI) in infants and it is estimated that globally 66,000–199,000 children younger than 5 years died from HRSV-associated ALRI in 2005 [1]. HRSV belongs to the Paramyxoviridae family and is an enveloped, negative sense, single-stranded RNA virus encoding 11 proteins [2]. HRSV infection occurs preferentially through the apical surface of the most superficial layer of the polarized epithelium of the respiratory tract [3, 4]. Human Respiratory Syncytial Virus matrix protein interacts with cellular adaptor protein complex 3
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
