Abstract
PurposeSleep disturbances and anxious symptoms are very common in people with type 2 diabetes mellitus(T2DM). This study aimed to assess the interactive effects of poor sleep quality and anxious symptoms on the quality of life of people with T2DM.MethodsNine hundred and forty-four participants with T2DM were enrolled in a cross-sectional study. Demographic and physiological characteristics were recorded. Each participant completed a Chinese version of the Pittsburgh Sleep Quality Index, the Patient Health Questionnaire-9 and General Anxiety Disorder questionnaire, and the Diabetes Specificity Quality of Life scale. The products of poor sleep quality and anxiety were added to a logistic regression model to evaluate the multiplicative interactions, expressed as the relative excess risk of interaction, the attributable proportion of interaction, and the synergy index.ResultsPoor sleep quality and anxiety symptoms were associated with reduced quality of life. There was a significant interaction between poor sleep quality and anxiety symptoms; this combined effect significantly reduced quality of life scores by 6.09-fold. The relative excess risk of interactions was 1.36.ConclusionsThe combined effect of poor sleep quality and anxiety symptoms reduces quality of life in people with T2DM.Trial registrationChiCTR-IOP-16008045. Registered 3 March 2016.A clinical study to investigate gum infection in patients undergoing kidney dialysis.
Highlights
The prevalence of diabetes has been increasing globally, with an estimated number of 592 million diabetes cases by 2035 [1]
Participants had an average duration of 5.6 ± 5.1 years since Type 2 diabetes mellitus diagnosis
We found that poor sleep quality was associated with a reduced Diabetes Specificity Quality of Life Scale (DSQL) score in participants with Type 2 diabetes mellitus
Summary
The prevalence of diabetes has been increasing globally, with an estimated number of 592 million diabetes cases by 2035 [1]. In China, more than 100 million people (approximately 1 in 10) have diabetes [2]. Because of unstable glycemic control, diabetes can affect any organ in the body, leading to serious complications over time [3]. Diabetes and its complications result in significant economic burden for individuals, families, and health care systems. To maintain control of blood glucose and reduce complications, people with diabetes require lifelong dietary restrictions, physical exercise, medication compliance, and blood glucose monitoring [5]. During this long-term, self-management process, many individuals experience emotional burdens and poor sleep quality in response to these prolonged requirements, including worry about complications, fear of
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