Abstract
In order to establish the contribution of Tyr 411 of human serum album in (HSA) to specific drug binding, the effect to drug binding on the fluorescence spectrum of HSA in which Tyr 411 was modified with p-nitrophenyl anthranilate (ANT-HSA) was studied by using various drugs (diazepam, chlordiazepoxide, fluenamic acid, indomethacin, azapropazone, phenylbutazone, warfarin, salcylic acid, ibuprofen, L-tryptophan, tolbutamide and sulfadimethoxine). Among these durugs, indomethacin and flufenamic acid strongly quenched the fluorescence of the anthraniloyl group of ANT-HSA at a molar ratio of 1.0, indicating that these drugs bind near the Tyr 411 residue.
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