Abstract
Genistein, a main soy isoflavone, is well known as phytoestrogen and antioxidant but details of its interactions with lipid membranes are poorly understood. The aim of this work was to elucidate the interaction of genistein, its derivatives and quercetin with lipid bilayers using attenuated total reflection infrared spectroscopy technique. Measurements performed mainly on liposomes and assistantly on dehydrated lipid films enabled us to find that studied flavonoids intercalate into phospholipid bilayers. The temperature of chain-melting phase transition for isoflavone-mixed DPPC liposomes was determined. The changes of population of the trans/gauche conformers of lipid chains were studied. They exert rigidifying effect in hydrophobic core of bilayer and due to the formation of hydrogen bonds induce a new spatial arrangement of lipid molecules.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
