Abstract
Complexes between poly(vinyl pyrrolidone) and phenolic materials can be important in such drug applications as slow-release formulations, reduced physiological shock, and detoxification. Hydroquinone serves as a model compound for the phenobarbital type of drug. The interaction of poly(vinyl pyrrolidone) with hydroquinone is manifested by a turbidity which develops in aqueous solutions at low concentrations. Also, the intrinsic viscosity of the polymer is reduced by the addition of hydroquinone and other phenols. Near the turbidity point, the behaviour is similar to that in a 0-solvent. Crosslinked polymer in equilibrium with an aqueous hydroquinone solution lowers the concentration in a manner correlated by the Langmuir equation. The interaction by all criteria is much weaker in isopropyl alcohol than in water, and too small to be measured in dimethyl sulphoxide.
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