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Abstract
1. 1. Acetate and butanoate inhibited and hexanoate and octanoate increased the 14CO 2 production from 0.1 mM [1- 14C]-labelled 2-oxoisocaproate (KIC) and 2-oxoisovalerate (KIV) in rat hemidiaphragms. 2. 2. Octanoate increased KIC and KIV oxidation in rat soleus muscle, too, inhibited it in human skeletal muscle and had a divergent effect in rat and human heart slices. 3. 3. In rat hemidiaphragms octanoate primarily affected the process of oxidative decarboxylation. No effect was found on transamination rates of branched-chain amino acids and on the CO 2 production beyond α-decarboxylation. 4. 4. The reverse transamination of branched-chain 2-oxo acids and their incorporation into protein decreased in the presence of octanoate. 5. 5. Octanoate had no effect on KIC and KIV oxidation at higher 2-oxo acid concentrations and in hemidiaphragms from 3-day-starved rats. 6. 6. The observed interactions are discussed and related to regulatory mechanisms, which are known to affect the branched-chain 2-oxo acid dehydrogenase complex.
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