Abstract
The purpose of the present study was to investigate the interaction of naproxen (NAP) with ß-cyclodextrin (ß-CD) in ground mixtures. The effects of grinding on the physicochemical properties of NAP were studied by means of IR spectroscopy and X-ray diffraction analysis. Ground mixtures of NAP with ß-CD and microcrystalline cellulose (MCC) were prepared by grinding a ceramic ball mill. The dissolution rate of NAP from the ground mixtures was significantly greater than that from physical mixtures and intact NAP powder. The ground mixture with ß-CD showed the fastest dissolution profile. These results indicate that ß-CD can enhance the dissolution rate of NAP.
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