Abstract
N-Methyl phenazinium radical cation (MPH +•) is known to interact with DNA in a manner analogous to an acridine dye (1). In the present communication, we have investigated the interaction of MPH +• with single stranded polyriboadenylic acid (poly A) through the combined use of electron paramagnetic resonance (EPR) and Fourier-transform proton magnetic resonance (FT-PMR). Use of a paramagnetic dye enables us to obtain average distances between three protons of poly A nucleotide and the unpaired electron on the dye, giving direct evidence for the π-π complexation of the dye with the adenine base. In addition, kinetic parameters for the complexation reaction are evaluated.
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