Interaction of moxifloxacin hydrochloride with sodium dodecyl sulfate and tween 80: Conductivity & phase separation methods

Abstract

Herein, antibiotic moxifloxacin hydrochloride (MFH) drug interaction with surfactants has been studied by means of the conductometric as well as cloud point (TCP) measurement techniques in the absence and presence of different electrolytes. In this study sodium dodecylsulfate (SDS) and Tween-80 (Tw-80) were used as anionic and non-ionic surfactants respectively. For pure surfactant (SDS) and (SDS+MFH) mixture two clear critical micelles concentration (c⁎) values denoted by c*1 (first) and c*2 (second) were observed. Variation of the c⁎ values in various systems signifies the interaction among the studied systems. The spontaneous surfactant assembly and stability of that aggregates were illustrated from the negative ∆G0m values of SDS/(SDS + MFH) in the H2O/ H2O + electrolytes medium. From ∆H0m and ∆S0m values it is clear that hydrophobic and electrostatic interactions are present between SDS as well as MFH. Various thermodynamic parameters of micellization were also determined. In the clouding phenomenon of Tw-80, the cloud pint (TCP) values were decreased with the enhancing content of Tw-80. In the presence of drug + salts, the TCP values decreased dramatically with additive concentration. The obtaining ∆G0c values were positive which indicates the non-spontaneity of clouding. On the other hand, the values of ∆H0c and ∆S0c show the presence of electrostatic/ hydrophobic relations among MFH & Tw-80. Various thermodynamic properties of transfer were also determined as well as explained thoroughly for both studied systems.