Abstract
Partial molar volume (Vϕ0) and partial molar isentropic compressibility (κsϕ0) values of drugs methimazole and curcumin in 25μmol·kg−1 human serum albumin (HSA) solution have been evaluated using density and speed of sound data. The isentropic compressibility values (ϕκs) of (curcumin/methimazole+HSA) solutions have also been computed. The ϕκs values decrease with an increase in the molal concentration of drugs as well as with temperature. The variations of trends of ϕκs for the studied drugs have been discussed in terms of structure breaking behavior of drugs. The values of Vϕ0 and κsϕ0 have been interpreted in terms of electrostatic and hydrophobic interactions operative in the solutions.
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