Abstract
Local anesthetic monohydrochlorides of [2-(alkoxy)phenyl]-2-(1-piperidinyl)ethyl esters of carbamic acid (CnA, n=2, 3, 4, 6, 8, 10, 12 is the number of carbon atoms in the alkyloxy substituent) increase the probability of formation of gauche isomers p g and decrease the effective energy difference between gauche and trans conformation E g in egg yolk phosphatidylcholine (EYPC) acyl chains, as determined by electron spin resonance spectroscopy using dipalmitoylphosphatidylcholines labeled with the paramagnetic dimethyloxazolidinyl group on the 12-th or 16-th carbon atoms of their sn-2 acyl chain, and oriented EYPC bilayers hydrated at 81% relative water vapour pressure. CnAs also increase the hydration of EYPC in non-oriented bilayers at the same relative water vapour pressure. At the molar ratio of CnA:EYPC=0.4:1, the maximum effect on p g, E g and hydration has been observed for intermediate alkyloxy chain lengths n≈4÷6.
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