Abstract
Committed hematopoietic progenitor cells are derived from pluripotent stem cells which have the capacity for both self-renewal and the generation of progeny which can differentiate along lineage-specific pathways. Although much is known about the humoral factors involved in regulating the proliferation and differentiation of committed hematopoietic progenitor cells, the role of humoral factors in the proliferation of pluripotent hematopoietic stem cells is largely undefined. Cerny demonstrated that products secreted by activated T lymphocytes stimulated the in vitro proliferation of pluripotent hematopoietic stem cells (1) and subsequently it was observed that medium conditioned by mitogen-stimulated spleen cells promoted the in vitro clonal growth of multipotent hematopoietic progenitors (2,3,4). These observations suggested that lymphokines might be involved in the regulation of pluripotent hematopoietic stem cells.
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