Abstract
In the rat stimuli which increase thirst decrease feeding. This study investigated the possibility that the suppression of feeding by hypertonic saline is mediated by the preoptic area. Feeding in rats with lesions in the lateral preoptic area was suppressed by increased osmolality even though these rats did not drink to hypertonic saline. Some of these rats with lesions in the preoptic area did not drink to the extracellular thirst stimulus, isoproterenol, but feeding was suppressed by the substance. Therefore the suppression of feeding by hypertonic saline and isoproterenol can be separated from the effect of these substances on water intake. It is unlikely that the interaction between hunger and thirst takes place in the preoptic area. Hypertonic saline and isoproterenol may act on other thirst systems or directly on feeding systems to decrease food intake.
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