Abstract
This work carried out a study on the interaction between harmine and oligonucleotide d(GTGCAC) 2. The binding thermodynamic parameters were obtained by ITC method. Harmine binds to oligonuleotide duplex d(GTGCAC) 2 in a fashion of intercalation mode and specific interaction and nonspecific interaction exist in the binding process. 1 H NMR experiments indicate that oligonucleotide d(GTGCAC) 2 is a generally self-complementary B-type duplex molecule, and harmine binds to DNA duplex d(GTGCAC) 2 at the side of methoxyl group preferentially in a mode of intercalation.
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