Abstract
The distribution of cytoskeleton elements (microtubules and actin filaments) and glucose transporters SGLT1 or GLUT2 in enterocyte of rat intestine and Caco2 cells during hexose absorption was studied. Confocal microscopy revealed that the distribution of SGLT1 and GLUT2 transporters in absorptive cells of the intestinal villus was altered depending on maltose concentration. The transporters were colocalized with actin. An increased number of vesicles close to microtubules in the apical cell part during absorption of high hexoze concentration was observed with electron microscopy. This observation, as well as uncovered colocalization of the transporters and actin, as well as actin and α-tubulin, suggests that elements of the cytoskeleton participate in the translocation of glucose transporters to the apical cell membrane.
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