Abstract
Schizophrenia is associated with many genetic and environmental risk factors and there is growing evidence that the interactions between genetic and environmental “hits” are critical for disease onset. Animal models of schizophrenia have traditionally used specific strain and housing conditions to test potential risk factors. As the field moves towards testing gene (G) x environment (E) interactions the impact of these choices should be considered. Given the surge of research focused on cognitive deficits, we have examined studies of cognition in rodents from the perspective of GxE interactions, in which strain or housing manipulations have been varied. Behavior is clearly altered by these factors, yet few animal models of schizophrenia have investigated cognitive deficits using different strain and housing conditions. It is important to recognise the large variation in behavior observed when using different strain and housing combinations because GxE interactions may mask or exacerbate cognitive outcomes. Further consideration will improve our understanding of GxE interactions and the underlying neurobiology of cognitive impairments in neuropsychiatric disorders.
Highlights
Schizophrenia is a complex group of disorders in which genetic vulnerability may lead to greater sensitivity to adverse environmental conditions (Bayer et al, 1999; van Os et al, 2008, 2010; Tost and Meyer-Lindenberg, 2012)
This article focuses on the consequences of strain and housing conditions on cognitive outcomes in rodent models of schizophrenia and how these factors may be useful in modeling GxE interactions
Schizophrenia develops from the complex interaction of GxE and we need to incorporate this complexity into animal models to understand the etiology of schizophrenia
Summary
Interaction of genotype and environment: effect of strain and housing conditions on cognitive behavior in rodent models of schizophrenia. Schizophrenia is associated with many genetic and environmental risk factors and there is growing evidence that the interactions between genetic and environmental “hits” are critical for disease onset. Animal models of schizophrenia have traditionally used specific strain and housing conditions to test potential risk factors. Given the surge of research focused on cognitive deficits, we have examined studies of cognition in rodents from the perspective of GxE interactions, in which strain or housing manipulations have been varied. Behavior is clearly altered by these factors, yet few animal models of schizophrenia have investigated cognitive deficits using different strain and housing conditions. It is important to recognise the large variation in behavior observed when using different strain and housing combinations because GxE interactions may mask or exacerbate cognitive outcomes.
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