Abstract
The interaction of phenytoin and furosemide was examined in rats. After 2 or more weeks of pretreatment with phenytoin, the diuretic activity of furosemide given orally was decreased. This was due primarily to a generalized decrease in absorption from the gastrointestinal tract. Following intravenous administration of furosemide to phenytoin pretreated rats, a decrease in diuretic activity also occurred. Excretion of furosemide was not altered. Thus, phenytoin pretreatment would also appear to interfere directly with the renal action of furosemide.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
