Interaction of excitation and inhibition in inferior collicular neurons of the big brown bat, Eptesicus fuscus

Abstract

Neurons in the inferior colliculus (IC) of the midbrain receive convergent excitatory and inhibitory inputs from both lower and higher auditory nuclei. Interaction of these two opposing inputs shapes different response properties of IC neurons. In this study, we examined this interaction of excitation and inhibition in IC neurons using a probe (excitatory pulse) and a masker (inhibitory pulse) under different stimulation conditions. Inhibition of probe-elicited responses by a masker, i.e. masking, occurred when the masker was presented at certain inter-pulse intervals (the temporal window) in relation to the probe. At the best inter-pulse interval, masking was maximal such that a neuron had the minimal number of impulses, the longest response latency, and the smallest excitatory frequency tuning curve. The temporal window for masking expanded with increasing masker duration. The inhibition decreased with increasing probe intensity but increased with increasing masker intensity. Increasing masker intensity also produced progressive shrinkage in excitatory frequency tuning curves. Similarly, increasing probe intensity produced progressive shrinkage of inhibitory frequency tuning curves. Possible mechanisms underlying the time and intensity dependence of inhibition are discussed.