Abstract
We have reported [(1984) Cancer Res., in press] that estramustine phosphate inhibits microtubule assembly and disassembled preformed microtubules. We now present evidence that estramustine phosphate inhibits microtubule assembly by binding to the microtubule-associated proteins. We have found that: (1) additional microtubule-associated proteins relieved the inhibition of assembly by estramustine phosphate; (2) 3H-labelled estramustine phosphate bound predominantly to the microtubule-associated proteins; and (3) the content of the microtubule-associated proteins was reduced in taxol reversed estramustine phosphate-inhibited microtubules.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.