Abstract
The focus of the present work is to evaluate the interactions of an anti-allergic drug (diphenhydramine hydrochloride, DPH) with anionic (sodium dodecyl sulfate, SDS) and cationic (cetylpyridinium chloride, CPC) surfactants in the aqueous medium. The mixed micellization behavior and surface properties of drug-surfactant mixtures have been examined by surface tension measurements. Various theoretical approaches were applied to explore the synergistic or non-ideal behavior of the current mixed systems. Furthermore, the binding studies of drug with surfactants have been elaborated by UV–visible spectroscopy. Benesi–Hildebrand (B-H) theory was used to compute stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures. The outputs are deliberated taking into consideration the use of surfactants as capable drug delivery agents for DPH and hence advance bioavailability.
Highlights
A pharmaceutical drug or medicine is a substance that causes physiological changes in the human body and is used to treat or cure a disease
The critical micelle concentration of single and mixed amphiphiles has been determined from surface tension vs. concentration plots (Figure 2)
The critical micelle concentration (CMC) value of DPH is decreased in the presence of Sodium dodecyl sulfate (SDS) and cetyl pyridinium chloride (CPC)
Summary
A pharmaceutical drug or medicine is a substance that causes physiological changes in the human body and is used to treat or cure a disease. The surface-active agents are organic molecules having both hydrophilic and hydrophobic parts in the same body. The presence of two opposite nature parts in the same body, allows these molecules to adsorb at the surface or interface and reduce the surface tension of the examine solution. The applications of these molecules are vast and in almost every field including household products, pharmaceuticals, biomedical, food industries, and cosmetics [22]. In pharmaceuticals the use of surface-active agents increases due to its self-assembling nature These surface-active agents can act as a solubilizer, stabilizers, and dispersion agent in pharmaceuticals. Micelle is a key point to provide various functional properties of the drug in the presence of different pharmaceutical excipients
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