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Abstract
Pancreatic exocrine secretion in the rat is inhibited by trypsin, chymotrypsin and elastase in the proximal small intestine (Green and Lyman, 1972; Schneeman and Lyman, 1973; Green and Levan, 1985). Recent studies have supported the hypothesis that this negative feedback control of pancreatic secretion is mediated by cholecystokinin (CCK). Orogastric administration of trypsin inhibitors to rats caused a transient reduction of intestinal levels of CCK (Brand and Morgan, 1981) and greatly increased plasma levels of CCK (Liddle, Goldfine and Williams, 1984). Diversion of bile-pancreatic juice from the intestine increased plasma CCK levels, which were returned to normal by intraduodenal infusion of trypsin (Louie et al, 1985; Fölsh et al, 1984). The mechanism by which pancreatic proteases inhibit CCK release is not known. Miyasaka and Green (1983) hypothesized that trypsin inhibited pancreatic secretion by inactivating an intraluminally-secreted peptide, possibly a CCK-releasing factor.
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