Abstract
Cytochrome c was permitted to react with several lipid monolayers in which surface pressure, lipid charge and unsaturation were varied. Cytochrome c interaction with the films caused increased surface pressures, and the magnitude and rate of surface pressure change were compared under a variety of experimental conditions. Large surface pressure changes were associated with more expanded films, whereas greater rates of surface pressure change were associated with favorable charge interaction between cytochrome c and the films. Under the most favorable conditions, rates of surface pressure change were limited principally by protein diffusion to the interface. From these data, it is suggested that unsaturation in lipids of biological membranes may help stabilise non-polar protein-lipid interactions, whereas charge interaction may facilitate and direct initial binding of protein to membranes.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Biomembranes
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