Abstract
HVJ (Sendai virus) and herpes simplex virus, which are both enveloped viruses, have receptors for concanavalin A, but poliovirus, which has no envelope, has no receptors. The HA activity of HVJ was not lost on exposure to concanavalin A; it seems that the sites on HVJ adsorbing concanavalin A differ from the active site of its hemagglutinin. After treatment with excess concanavalin A, HVJ or herpes virus became non-infectious. This state was reversed by washing these viruses with α-methylmannoside, which is a specific inhibitor of concanavalin A. Embryonated eggs, a host of HVJ, and FL cells, a host of herpes virus and poliovirus can adsorb concanavalin A onto their cell surfaces, and this prevents infection with these three viruses. This protection by concanavalin A was reversed by α-methylmannoside.
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