Abstract
The capacity of the hepatocarcinogen dimethylaminoazobenzene and two of its analogs to protect erythrocytes against hemolysis is demonstrated. The aminoazo dye compounds exhibit stabilization at relatively low final concentrations, suggestive of an efficient partitioning of the dye molecules into the erythrocyte membrane. Methyl groups at either the 2 or 3′ position of dimethylaminoazobenzene confer even greater stabilization potential to the basic dye structure. The application of the erythrocyte osmotic hemolysis assay in analysis of carcinogen-membrane interactions is discussed.
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