Abstract
The DNA binding properties of bleomycin A2 and its model compound, 2-(2-amino-4-thiazolyl)-4-thiazolecarboxylic acid, were studied by analyzing the spectroscopic changes induced when these molecules are in solution with calf thymus DNA, poly(dG–dC) and poly(dA–dT). Measurements were made of both the free and complexed materials, using electronic absorption, Raman (406.7 nm excitation) and UV resonance Raman (274 nm) spectroscopy. The results of our studies support and complement previous work by indicating that the bithiazole rings most likely interact with DNA via a groove-binding mechanism involving thymine and adenine bases in sequences other than –ATAT–. Copyright © 2000 John Wiley & Sons, Ltd.
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