Interaction of Atorvastatin-loaded magnetic iron oxide nanoparticles with DNA

Abstract

The present work aims to tether magnetic iron oxide nanoparticles onto a statin drug, Atorvastatin, in its free- and β-cyclodextrin-encapsulated form. The binding behavior of magnetic iron oxide nanoparticles tethered and β-cyclodextrin-encapsulated Atorvastatin to calf thymus DNA is studied by UV–Visible and fluorescence spectroscopy. The docking poses of Atorvastatin to β-cyclodextrin and DNA prove their binding toward the isopropyl and pyrrole moiety, respectively. The tethering of magnetic iron oxide nanoparticles and the encapsulation of β-cyclodextrin do not affect Atorvastatin’s binding strength toward DNA. The formation of the supramolecular ternary complex from free- and magnetic iron oxide nanoparticles tethered to Atorvastatin can be achieved with β-cyclodextrin and DNA for the drug’s better dissolution, bioavailability, and in-vivo medical applications.