Interaction of apolipoprotein AIV with cholecystokinin on food intake.

Abstract

Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are satiety peptides that act both peripherally and centrally to reduce food intake. Both Apo AIV and CCK suppressed food intake by decreasing meal size. The aim of the present study is to examine the effects of peritoneally administered bolus dose of (1) recombinant apo AIV; (2) CCK-8; and (3) a combination of sub-threshold doses of apo AIV and CCK on food intake in rats that were fasted overnight. Food intake was measured for 4 h following bolus injection. Apo AIV at 100 μg/kg reduced food intake significantly relative to the saline control ( p p p