Abstract
Cytosolic and nuclear progesterone receptors (PRc and PRn) under antiprogestin treatment were measured in rat deciduoma and compared with values for contralateral (non-deciduomatous) rat uterine tissue. Uterine PRc and PRn of the progesterone treated group were 101 ± 8.7 and 4770 ± 590 fmol/mg DNA respectively. After treatment with antiprogestins STS-557, 5α-DNE, (5α-dihydronorethisterone), 5a-DNG (5α-dihydronorgestrel), RU-22092 and RU-16556, PRc in the nondeciduomatous control horn ranged from 127 to 377 fmol/mg DNA and PRn from 2785 to 17925 fmol/mg DNA. In the decidual tissue, PRc decreased significantly (4.6 ± 0.8 fmol/mg DNA) on 5α-DNG treatment as compared with the progesterone alone treatment group (147 ± 3.8). PRn in decidual tissue also decreased maximally on 5α-DNG treatment. These results suggest that the interaction of antiprogestins may not be identical in control uterine tissue and in deciduoma.
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