Abstract
A family of synthetic mimic of antimicrobial peptides (SMAMP), amphiphilic meta-phenylene ethynylene (mPE) molecules show a wide range of antimicrobial activity and specificity. The interaction of a specifically active mPE molecule (AMO-2) with mixed DOPE/DOPG lipid was studied by solid-state NMR. The AMO-2 molecules do not preferentially interact more strongly with either lipid component, but rather are well dispersed in the lipid matrix. AMO-2 intimately interacts with all parts of lipid molecules, including head groups. Magic-angle spinning sideband analysis indicated that in samples with co-existing lamellar and inversed hexagonal phases (HII), neither lipid component aggregate in either phase. The presence of AMO-2 molecules causes dynamic disorder in lipid head groups, as evidenced by the broadening of both static and MAS 31P spectra. AMO-2 molecules do not massively transform the lamellar lipid into HII phase.
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