Abstract
The treatment of female rats with high doses of the synthetic androgens, 17α-methylandrostenediol (MAD) and 17α-methyltestosterone (MT), leads to inhibition of corticosterone formation from progesterone in adrenal homogenates. Mitochondria were isolated from the adrenals of control and treated animals and several changes were noted. 11β-Hydroxylation rates were about 40 and 70% of control rates in adrenal mitochondria from MT- and MAD-treated rats, respectively. Associated with the androgen treatment there was a doubling in the levels of cytochromes a and a 3 in the adrenal mitochondria with no change in the levels of cytochromes b or c and c 1. The cytochrome P-450 levels were about 60% of control levels in adrenal mitochondria isolated from MT- and MAD-treated rats. In addition to these alterations in adrenal mitochondria cytochrome levels, there was evidence that the MT was bound to the adrenal mitochondria. This binding resulted in lower DOC-induced spectral changes in adrenal mitochondria isolated from MT-treated rats. Such binding of androgen and the lower levels of cytochrome P-450 would appear to explain the decreased 11β-hydroxylation rates.
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