Abstract
The effect of two antidepressant drugs i.e., CPZ and PMZ on the colloidal behaviour of 1-decyl-3-methyl-imidazolium tetrafluoroborate [Dmim][BF4] ionic liquid has been studied and compared with the structurally similar cationic surfactant tetradecyltrimethylammonium bromide (TTAB). The micellization and interfacial parameters of [Dmim][BF4] and TTAB, in the presence of antidepressant drugs have been determined using conductivity and surface tension measurements. The aggregation number (Nagg) and Stern-Volmer constant (Ksv) have also been determined by fluorescence measurements. Various micellar and interfacial parameters of drug-surfactant system (CPZ/PMZ+[Dmim][BF4]/ CPZ/PMZ+TTAB) indicates favourable interaction between them. The dynamic light scattering measurements have also been employed for the size of aggregates. This study concluded that imidazolium based ionic liquid could probably act as better drug carriers than conventional cationic surfactants.
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