Interaction of Alcohol Consumption and ABCG2 rs2231142 Variant Contributes to Hyperuricemia in a Taiwanese Population.

I-Chieh Chen,Ching-Heng Lin,Yi-Ming Chen,Ying-Cheng Lin,Hsueh-Ju Lin,Pei-Chun Chen,Yen-Ju Chen,Jui-Chun Chagn

doi:10.3390/jpm11111158

Abstract

Background: ABCG2 rs2231142 is an important genetic factor that contributes to the development of gout and hyperuricemia (HUA). Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., ABCG2 gene) together, contribute to enhanced serum uric acid levels. However, the interaction between ABCG2 rs2231142, alcohol consumption, and HUA in the Taiwanese population is still unclear. Therefore, this study investigated whether the risk of HUA is associated with ABCG2 rs2231142 variants and how this is affected by alcohol consumption. Method: study subjects were selected from the participants of the Taiwan Biobank database. Overall, 114,540 participants aged 30 to 70 years were enrolled in this study. The interaction between ABCG2 rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. Results: the prevalence of HUA was 32.7% and 4.4 % in the male and female populations, respectively. In the whole study population, the minor T allele of ABCG2 rs2231142 was significantly associated with HUA risk, and the occurrence of HUA was high in TT genotype and TG genotype. The risk of HUA was significantly increased by the combined association of ABCG2 rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the ABCG2 rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the ABCG2 rs2231142 risk allele contributes to increased HUA risk.

Highlights

Uric acid is a product of purine metabolism in humans
In this study, we examined whether the different joint effects of alcohol consumption and ATP-binding cassette subfamily G member2 (ABCG2) rs2231142 risk allele in males and females contribute to increased HUA risk
The results indicated that the risk of HUA was significantly associated with ABCG2 rs2231142 risk T allele, as the risk for HUA increased by 91.8% in men (OR = 1.918, 95% confidence interval (95% CI): 1.834–2.005, p < 0.001) and 87.4% in women (OR = 1.874, 95% CI: 1.735–2.025, p < 0.001) with TG/TT genotype

Summary

Introduction

Uric acid is a product of purine metabolism in humans. A high blood concentration of uric acid is known as hyperuricemia (HUA, uric acid levels > 7.0 mg/dL), which can be caused by an imbalance in uric acid uptake, synthesis, or excretion [1,2], and is related to gout, cardiovascular disease, chronic kidney disease, type 2 diabetes mellitus [2,3,4,5], and metabolic related diseases [6,7]. Epidemiologic studies have demonstrated that lifestyle risk factors of HUA (e.g., alcohol consumption) and genetic predisposition (e.g., ABCG2 gene) together, contribute to enhanced serum uric acid levels. This study investigated whether the risk of HUA is associated with ABCG2 rs2231142 variants and how this is affected by alcohol consumption. The interaction between ABCG2 rs2231142, alcohol consumption, and serum uric acid (sUA) levels was analyzed by multiple logistic regression models. The risk of HUA was significantly increased by the combined association of ABCG2 rs2231142 and alcohol consumption for TG/TT genotype compared to the GG genotype (wild-type genotype), especially among women. Conclusion: the ABCG2 rs2231142 is a crucial genetic locus for sUA levels in the Taiwanese population and our findings revealed that alcohol consumption combined with the ABCG2 rs2231142 risk allele contributes to increased HUA risk

Methods

Results

Discussion

Conclusion