Abstract
This article deals with the interaction bet ween the preservative 8-hydroxyquinoline sulfate (8-HQS) and the surface-active agent polysorbate 80. In buffered solution (pH 7.38) 8-HQS is dissociated to 8-hydroxyquinoline (8-HQ) and H<sub>2</sub>SO<sub>4</sub>, and it is the base 8-HQ that forms a reversible association with polysorbate 80. The degree of binding of 8-HQ to polysorbate 80 was shown to be a function of the concentration of the nonionic surface-active agent. Polysorbate 80 at low concentration (about 0.00 5 per cent) has practically no effect on the concentration of 8-HQ in a buffered solution (pH 7.38) as used for preparing dilutions of tuberculin PPD for the intracutaneous met hod (Mantoux test). 8-HQS, in a buffered solution of pH 3, does not interact with polysorbate 80.
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