Abstract
Methotrexate elimination may be delayed by different drugs. Such a delay may produce severe toxic complications. Case reports. – We report two cases of adolescents treated for malignant diseases who presented a delayed methotrexate elimination even though they received ciprofloxacin. The first patient had already received several courses of methotrexate without toxicity before this episode. The second patient tolerated methotrexate when ciprofloxacin was not associated to the treatment. Conclusion. – High-dose methotrexate-ciprofloxacin association should be avoided.
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