Interaction between Urinary 11 Dehydrothromboxane B2 and Some Other Risk Factors in the Occurrence of Cerebral Infarction

Wang Lingling,Li Wei,Sun Hua,Chen Guixin

doi:10.2174/1874220301603010089

Abstract

Objective:The objective of this study is to analyze the interaction between the urinary 11-dehydrothromboxane B2 (11-DH-TXB2) content and the smoking, drinking, hypertension or diabetes history of patients with cerebral infarction, and to determine the value of 11-DH-TXB2 in the occurrence and prevention of cerebral infarction.Methods:117 patients with cerebral infarction and 50 healthy controls were selected. Their general information, including smoking, drinking, hypertension and diabetes history, was analyzed, and their urinary11-DH-TXB2 contents were measured. The difference in the urinary 11-DH-TXB2 content between the two groups, and the additive model of the interaction between the urinary 11-DH-TXB2 content and other risk factors of cerebrovascular diseases were statistically analyzed.Results:There was no significant difference in the general information between the two groups (P> 0.05). Significant differences were observed in the urinary 11-DH-TXB2 content, and the smoking, diabetes and hypertension history between the two groups, while there was no significant difference in the drinking history between the two groups. The analysis of the interaction additive model showed that the OR value was 1, the synergy index (S) of increased 11-DH-TXB2 and smoking history was 1.219, the S of increased 11-DHTXB2 and hypertension history was 5.578 and that of increased 11-DH-TXB2 and the diabetes history was 4.604.Conclusion:There is a correlation between the urinary 11-DH-TXB2 content and the occurrence of cerebral infarction, and there is a synergistic interaction between the urinary DH-TXB2 content and the smoking, hypertension or diabetes history of patients with cerebral infarction. The increased 11-DH-TXB2 may be a risk factor for cerebral infarction and the urinary 11-DHTXB2 content can be used as an index to predict the occurrence and progression of cerebral infarction.

Highlights

Cerebral infarction is a common disease with high incidence and irreversible damage to neurological function caused by cerebral ischemia and anoxic necrosis due to various reasons [1]
There was no significant difference in the demographics of the subjects and in the history of alcohol consumption between the cerebral infarction group and noncerebral infarction group(P> 0.05), and there were significant differences in the smoking, hypertension and diabetes history (P< 0.05)
The relevant research results show that platelets can directly act as an “inflammatory cell” to participate in the formation of atherosclerosis [2]: (1) In the early stage, platelets mainly interact with monocytes and vascular endothelial cells, the platelets and monocytes adhere to each other to activate the monocytes, and the monocytes further adhere to the vascular endothelial cells, driving the monocytes to migrate and accumulate in the intima of blood vessels; (2) In the late stage, platelets aggregate on the erosive and ruptured plaques to cause secondary thrombosis, leading to a series of acute or chronic clinical events

Summary

Introduction

Cerebral infarction is a common disease with high incidence and irreversible damage to neurological function caused by cerebral ischemia and anoxic necrosis due to various reasons [1]. The urinary 11-DHTXB2 content of patients with cerebral infarction, and the interaction between urinary 11-DH-TXB2 and some other risk factors of cerebral infarction were retrospectively analyzed to provide a scientific basis for the urinary 11-DH-TXB2 as a risk factor for the primary prevention of cerebral infarction

Methods

Results

Discussion

Conclusion