Abstract
Abstract The role of monoamine oxidase in the potentiation of the pressor effect of phenylpropanolamine (norephedrine) by monoamine oxidase inhibitors has been investigated. In vitro, phenylpropanolamine was not a substrate of monoamine oxidase from guinea-pig liver. In spinal cats the pressor effects of both phenylpropanolamine and tyramine were potentiated by a monoamine oxidase inhibitor, nialamide, and by the microsomal enzyme inhibitor SKF 525-A, which is not a monoamine oxidase inhibitor. These results suggest that the enhanced pressor effect of phenylpropanolamine in the presence of monoamine oxidase inhibitors is caused by inhibition of other enzymes.
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