Abstract
Median eminence extracts (ME) incubated with oxytocin produced the formation of a melanocyte-stimulating hormone-release-inhibiting factor (MSH-R-IF). When extracts of paraventricular nucleus (PVN) were added to that system and incubated together no formation of MSH-R-IF was detected. The effect of PVN extracts is due not to the inactivation of MSH-R-IF, and is proportional to the amount of extract used. PVN extracts were effective in preventing the formation of MSH-R-IF when 150 mU oxytocin were used as substrate but not when 1000 mU were used, suggesting that the mechanism by which the blocking effect is exerted is similar to that of two enzymes competing for the same substrate. It is postulated that MSH-R-IF formation depends of two hypothalamic agents of antagonistic influence acting on oxytocin.
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