Abstract
Prototype strains of human adenoviruses types 1–3, 5–8 do not multiply in GMK cells and could not be adapted to them during several blind passages. Simian adenoviruses SA7(C8), SA7(B105), SV32, and SV38 can serve as helpers for replication of human adenoviruses in this system. Simultaneous infection of GMK cells with human and simian adenoviruses leads to the replication of both viruses. As a result of phenotypic mixing homologous and heterologous antigenic determinants are incorporated in the capsid of most virions. In the virus yield obtained after mixed infection, the appearance of virions with human adenovirus capsids capable of replicating in GMK cells was demonstrated. Such virions seem to be formed as a result of “hybridization” of original adenoviruses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
