Abstract
AbstractThe interaction of Mg2+, Ca2+, Mn2+, and Cu2+ ions with the DNA macromolecule is studied in a wide range of ionic strengths, 2 · 10−4 to 10−1 mol · 1−1. It is shown that the observed considerable changes in the intrinsic viscosity and the excluded volume parameter of DNA are due to the screening of the phosphate groups and nitrogen bases of DNA during the direct binding of the ions. The bivalent ion binding to DNA leads to suppression of the effects of the long‐range interactions in the macromolecules at concentrations two or three orders of magnitude lower than those for monovalent ions. The intrinsic viscosity and the excluded volume parameter are universally dependent on the ion binding degree.
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