Abstract
The interaction between DNA and histone in strong saline at neutrality was studied by viscometry and sedimentation measurements. The results obtained with calf thymus nucleohistone and with artificial mixtures of DNA and histone were in good agreement. Viscosity and sedimentation coefficient varied markedly with the sodium chloride concentration, but neither depolymerization nor aggregation of the DNA molecule appears to be involved. In relatively weak saline solution ( e.g., i M NaCl), a complex of DNA and histone I exists, which complex dissociates progressively with increase in salinity. Other strongly basic proteins studied thus far showed practically no interaction with DNA even in relatively weak saline solution, although the mixtures with DNA gave fibrous precipitates of “nucleoprotein” in physiological saline.
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